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Delayed changes in neural visinin-like calcium-binding protein gene expression caused by acute phencyclidine
Y Kajimoto1, O Shirakawa, T Kuno
1Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan.
Journal of Neural Transmission. General Section
|January 1, 1995
Abstract:
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca(2+)-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca(2+)-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.