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Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases
1Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.
Journal of Neural Transmission. General Section
|January 1, 1995
Abstract:
To investigate whether nitric oxide (NO) plays a role in degenerative neurologic disease (DND), we measured nitrite, nitrate and cyclic GMP in cerebrospinal fluid (CSF) samples from patients with Parkinson's disease (PD), spinocerebellar ataxia (SCA) and amyotrophic lateral sclerosis (ALS). We found no significant change in CSF nitrite, nitrate or cyclic GMP in patients with any DND compared with control values. These results suggest that NO production is preserved in PD, SCA and ALS.