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Related Experiment Videos

Endogenous pyrogen-like substance produced by reptiles

H A Bernheim, M J Kluger

    The Journal of Physiology
    |June 1, 1977
    PubMed
    Summary

    Lizards injected with rabbit or lizard endogenous pyrogen developed fevers, while denatured pyrogens had no effect. This suggests fever mechanisms in advanced vertebrates may originate in primitive species.

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    Area of Science:

    • Comparative physiology
    • Thermoregulation
    • Evolutionary biology

    Background:

    • Endogenous pyrogens are molecules that induce fever.
    • The evolutionary origins of fever mechanisms are not fully understood.
    • Vertebrate thermoregulation exhibits diverse strategies.

    Purpose of the Study:

    • To investigate the role of endogenous pyrogens in reptilian fever.
    • To explore the evolutionary conservation of fever-inducing mechanisms.
    • To determine if lizard fever responses are analogous to those in mammals.

    Main Methods:

    • Injection of desert iguanas (Dipsosaurus dorsalis) with rabbit and lizard endogenous pyrogens.
    • Administration of denatured pyrogens as controls.
    • Monitoring of lizard body temperature changes post-injection.

    Main Results:

    • Injection with active rabbit and lizard endogenous pyrogens induced fever in Dipsosaurus dorsalis.
    • Denatured pyrogens did not elicit a febrile response.
    • The fever induced by lizard pyrogen was of short duration.

    Conclusions:

    • Endogenous pyrogens play a role in inducing fever in lizards.
    • The febrile mechanism in lizards shares similarities with higher vertebrates.
    • These findings support the hypothesis of an ancient origin for vertebrate fever mechanisms.

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