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Phase II enzymes and bioactivation

J A Hinson¹, P G Forkert

¹Department of Pharmacology and Toxicology, Division of Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Canadian Journal of Physiology and Pharmacology

|October 1, 1995

Summary

This summary is machine-generated.

Phase II enzymes can activate, not just detoxify, drugs and chemicals. Glutathione conjugates, for example, can lead to toxicity, while esterases aid in detoxification and drug metabolism.

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Area of Science:

Biochemistry
Toxicology
Pharmacology

Background:

A colloquium honoring Dr. James R. Gillette's contributions to drug metabolism and toxicity was held.
The focus was on Phase II enzymes and bioactivation, particularly the dual role of conjugation reactions.