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Related Experiment Videos

Serotonergic modulation of cat bladder function before and after spinal transection

M J Espey1, J W Downie

  • 1Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.

European Journal of Pharmacology
|December 12, 1995
PubMed
Summary

Serotonin (5-HT) and its receptors play a role in bladder control. Spinal transection alters some, but not all, of this serotonin-mediated bladder function.

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Area of Science:

  • Neuroscience
  • Urology
  • Pharmacology

Background:

  • Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in various physiological processes.
  • The role of serotonergic pathways in the regulation of micturition is not fully understood, particularly after spinal cord injury.

Purpose of the Study:

  • To investigate the role of serotonin and 5-HT3 receptors in the control of micturition in cats.
  • To determine how spinal transection affects serotonergic modulation of bladder function.

Main Methods:

  • Micturition was induced in conscious cats by bladder saline infusion.
  • Drugs, including serotonin, zatosetron (a 5-HT3 antagonist), and 2-methyl-5-HT (a 5-HT3 agonist), were administered intrathecally.
  • Experiments were conducted in both spinally intact and spinally transected cats.

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Main Results:

  • In spinally intact cats, serotonin increased the micturition volume threshold, indicating 5-HT3 receptor inhibition of micturition.
  • Zatosetron decreased the micturition volume threshold.
  • After spinal transection, serotonin reduced the volume threshold in most cats, suggesting altered serotonergic control.
  • However, a 5-HT3 receptor agonist still increased the volume threshold, indicating preserved 5-HT3 receptor-mediated inhibition.

Conclusions:

  • Serotonin modulates bladder function through 5-HT3 receptors, generally inhibiting micturition.
  • Spinal transection alters some aspects of serotonergic control over bladder function.
  • Despite alterations, 5-HT3 receptor-mediated inhibition of bladder function persists after spinal transection.