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Effects of loratadine on postural control
T Ledin1, L M Odkvist, C Möller
1Department of ENT, University Hospital, Linköping, Sweden.
Acta Oto-Laryngologica. Supplementum
|January 1, 1995
Summary
Loratadine, a non-sedating antihistamine, showed no adverse effects on balance. Unlike clemastine, loratadine did not impair equilibrium in healthy subjects, indicating its safety for balance functions.
Area of Science:
- Pharmacology
- Neuroscience
- Vestibular System Research
Background:
- Sedating antihistamines can impair cognitive and perceptual functions.
- Loratadine is a newer antihistamine known for its lack of sedative effects.
- Assessing the impact of non-sedating antihistamines on balance is crucial for patient safety.
Purpose of the Study:
- To evaluate the effects of loratadine on equilibrium in healthy subjects.
- To compare the effects of loratadine with a sedating antihistamine (clemastine) and placebo on balance.
- To determine the safety profile of loratadine concerning vestibular and balance functions.
Main Methods:
- A double-blind, placebo-controlled study involving 8 healthy adult subjects.
- Administration of loratadine (10 mg and 40 mg daily), clemastine (2 mg twice daily), and placebo.
- Assessment of equilibrium using dynamic posturography, including sensory organization and movement coordination tests.
Main Results:
- Analysis of variance revealed no statistically significant effects of loratadine on overall equilibrium.
- Pairwise comparisons showed a significant difference between loratadine and clemastine in 2 out of 6 sensory test conditions.
- No significant balance impairment was observed with loratadine at the tested dosages.
Conclusions:
- Loratadine can be considered safe concerning balance functions.
- The non-sedating antihistamine loratadine does not appear to negatively impact equilibrium.
- Results suggest loratadine offers a safer alternative for individuals concerned about antihistamine-induced balance disturbances.