Hinge-bending motion in citrate synthase arising from normal mode calculations
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Updated: Nov 5, 2026

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Published on: August 13, 2020
1C.E.R.F.A.C.S., Toulouse, France.
Abstract:
A normal mode analysis of the closed form of dimeric citrate synthase has been performed. The largest-amplitude collective motion predicted by this method compares well with the crystallographically observed hinge-bending motion. Such a result supports those obtained previously in the case of hinge-bending motions of smaller systems, such as lysozyme or hexokinase. Taken together, all these results suggest that low-frequency normal modes may become useful for determining a first approximation of the conformational path between the closed and open forms of these proteins.
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