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Related Experiment Videos

MRI-based hippocampal volumetrics: data acquisition, normal ranges, and optimal protocol

C R Jack1, W H Theodore, M Cook

  • 1Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.

Magnetic Resonance Imaging
|January 1, 1995
PubMed
Summary

Precise magnetic resonance (MR) volume measurements require careful acquisition and postprocessing. "Normal" hippocampal volume varies significantly due to differing methods, necessitating institution-specific calibration for accurate research and clinical use.

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Area of Science:

  • Neuroimaging
  • Biomedical Engineering
  • Radiology

Background:

  • Accurate magnetic resonance (MR) volume measurements are crucial for clinical and research applications.
  • Standardized protocols for MR data acquisition and postprocessing are essential for precise and reproducible volumetric analysis.
  • Existing studies show considerable variability in reported "normal" hippocampal volumes in healthy adults.

Purpose of the Study:

  • To highlight the importance of both MR data acquisition and postprocessing for accurate volumetric measurements.
  • To address the wide range of "normal" hippocampal volumes reported in the literature.
  • To emphasize the need for institution-specific calibration of volumetric measurement techniques.

Main Methods:

  • The study discusses the general principles of MR data acquisition and postprocessing for volumetric analysis.

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  • It reviews existing literature on hippocampal volume measurements in normal volunteers.
  • The text emphasizes the technical dependency of volumetric output.

    • Main Results:

    • Significant interinstitutional variability exists in hippocampal volume measurements.
    • This variability is attributed to differences in hippocampal boundary criteria and region of interest (ROI) software.
    • The numeric output of MR volume measurement procedures is highly technique-dependent.

    Conclusions:

    • Precise and reproducible MR volume measurements depend on meticulous attention to both acquisition and postprocessing.
    • The wide variability in "normal" hippocampal volumes necessitates that each institution determine or calibrate its own statistical descriptions.
    • Standardized calibration at each institution is vital for reliable clinical and research volumetrics.