Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homeostatic maintenance regulated by hypothalamic neuronal histamine

T Sakata1, H Yoshimatsu

  • 1Department of Internal Medicine I, Oita Medical University, Japan.

Methods and Findings in Experimental and Clinical Pharmacology
|November 1, 1995
PubMed
Summary

Hypothalamic histamine regulates feeding and energy balance. Defects in this system cause obesity, highlighting histamine

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Associated with Lower Extremity Dysmorphia Caused by Lower Extremity Lymphoedema.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2017
Same author

Myocardial torsional deformations in cats with hypertrophic cardiomyopathy using two-dimensional speckle-tracking echocardiography.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2016
Same author

Thermoregulation modulated by hypothalamic histamine in rats.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2016
Same author

Indocyanine Green Lymphography Findings in Primary Leg Lymphedema.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2014
Same author

A c-fos-monomeric red fluorescent protein 1 fusion transgene is differentially expressed in rat forebrain and brainstem after chronic dehydration and rehydration.

Journal of neuroendocrinology·2013
Same author

Hypothalamic brain-derived neurotrophic factor regulates glucagon secretion mediated by pancreatic efferent nerves.

Journal of neuroendocrinology·2012

Area of Science:

  • Neuroscience
  • Endocrinology
  • Metabolism

Background:

  • Homeostatic energy balance is crucial for survival.
  • The hypothalamus plays a key role in regulating energy intake and expenditure.
  • Neuronal histamine is implicated in various brain functions, including appetite control.

Purpose of the Study:

  • To investigate the role of hypothalamic neuronal histamine in regulating feeding behavior and energy homeostasis.
  • To explore the effects of histamine receptor manipulation on satiety and energy intake.
  • To elucidate the mechanisms underlying obesity in Zucker rats and the potential involvement of histamine.

Main Methods:

  • Experiments were conducted on non-obese normal and genetically obese Zucker rats.
  • Histamine H1 and H3 receptors in the ventromedial hypothalamic nucleus (VMH) and paraventricular nucleus were manipulated.

Related Experiment Videos

  • Feeding behavior, drinking, and energy intake were monitored.
  • Neuronal histamine levels and activity were assessed under various conditions, including glucoprivation and thermal challenges.
  • Fetal hypothalamic grafts were used to study the impact of hypothalamic structure on obesity.

    • Main Results:

    • Activation of H1 receptors or inhibition of H3 receptors in the VMH suppressed feeding and accelerated drinking.
    • Intraneuronal glucoprivation led to satiation via histaminergic activation of VMH neurons.
    • Histamine neurons in the mesencephalic trigeminal nucleus (Me5) influenced eating speed, while VMH neurons controlled meal volume.
    • Hypothalamic histamine neurons were activated by high ambient temperature and interleukin-1beta, suggesting a role in thermoregulation.
    • Obese Zucker rats exhibited behavioral and metabolic abnormalities linked to defective hypothalamic neuronal histamine.
    • Depleting neuronal histamine in normal rats mimicked obese Zucker phenotypes.
    • Fetal hypothalamic grafts attenuated obesity-related abnormalities in Zucker rats.

    Conclusions:

    • Hypothalamic neuronal histamine is a critical regulator of feeding behavior, satiety, and energy homeostasis.
    • Dysfunction in the hypothalamic histamine system contributes to the development of obesity.
    • Targeting histamine pathways in the hypothalamus may offer therapeutic strategies for metabolic disorders.