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Updated: Aug 7, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[Acute pancreatitis caused by valproic acid: apropos a case]
A Bahamonde Carrasco1, A Morán Blanco, J L Olcoz Goñi
1Servicio de Medicina Interna, Hospital de León.
Valproic acid can cause acute pancreatitis, a severe side effect likely due to idiosyncratic reactions. Monitor patients for symptoms and pancreatic enzymes if this rare complication is suspected.
Area of Science:
- Neurology
- Gastroenterology
Background:
- Valproic acid is a widely used antiepileptic and mood-stabilizing drug.
- Acute pancreatitis is a known, though rare, adverse effect associated with valproic acid therapy.
Observation:
- This report details a new case of valproic acid-induced pancreatitis.
- A comprehensive review of existing literature on this adverse event is also presented.
Findings:
- Valproic acid-induced pancreatitis is likely an idiosyncratic reaction, meaning it is unpredictable and not dose-dependent.
- Diagnosis relies heavily on clinical suspicion due to the rarity and varied presentation.
Implications:
- Healthcare providers should maintain strict clinical surveillance of patients on valproic acid.
- Monitoring pancreatic enzymes is crucial when symptoms suggestive of pancreatitis arise to ensure timely diagnosis and management.
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