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Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient
Fertility and Sterility
|July 1, 1996
Abstract
Objective:
To achieve fertilization and cleavage by spermatids without tails from testicular biopsy.
Design:
Clinical trial.
Setting:
Reproductive unit of a university teaching hospital.
Patient:
A patient of obstructive azoospermia with defective spermiogenesis.
Intervention:
Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte.
Main Outcome Measures:
Fertilization and cleavage.
Results:
Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved.
Conclusion:
Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.