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[Drug-to-drug interactions and pharmaceutical advice]

A Sáenz Calvo1, M Ausejo Segura, E Cruz Martos

  • 1Centro de Salud Gómez Acebo, Insalud, Area/Sector XI de Madrid.

Atencion Primaria
|May 31, 1996
PubMed
Summary

Seven drug groups cause most primary care drug interactions, increasing with more prescribed medications. Older adults over 55 were most affected, with general practitioners accepting most pharmacist recommendations.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Drug Safety

Context:

  • Primary healthcare setting in Madrid, Spain.
  • Involves 145 patients on multiple medications.
  • Collaboration between general practitioners and a pharmacist.

Purpose:

  • To identify common drug-drug interactions in primary care.
  • To analyze the types of drugs most frequently involved in interactions.
  • To assess the acceptance rate of pharmacist recommendations by general practitioners.

Summary:

  • A 1-month study identified 333 drug interactions in 145 patients.
  • Theophylines, diuretics, antacids, benzodiazepines, beta-blockers, NSAIDs, and ACE inhibitors were implicated in 67.5% of interactions.
  • General practitioners accepted 74% of pharmacist-proposed interventions.

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Impact:

  • Highlights key drug classes contributing to interactions in primary care.
  • Demonstrates the positive impact of pharmacist intervention on drug safety.
  • Provides data on the relationship between polypharmacy and drug interactions.