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[Impact of anesthetic technic (general anesthesia versus intradural anesthesia) on the immune status]
C Muriel1, A García-Sánchez, F Sánchez
1Servicio de Anestesiología y Reanimación, Hospital Universitario de Salamanca.
Objective:
To study changes in the immune system appearing after general and regional (intradural anesthesia).
Patients And Methods:
Fifty patients scheduled for elective surgery to repair inguinal hernias were studied. The patients were randomly assigned to 2 groups: group A patients received general anesthesia and group B patients received intradural anesthesia. Blood was extracted 5 times to determine levels of lymphocytes, activated T cells and B lymphocytes, and T-suppressant activity: t0 (before surgery), t1 (1 h), t2 (4 h), t3 (24 h) y t4 (7 days).
Results:
The patients in group A showed slight increases in T lymphocytes, activated T lymphocytes and B lymphocytes, whereas T-suppressant activity decreased significantly. All lymphoid population decreased in group B. Baseline levels had recovered in both groups by 7 days after surgery.
Conclusion:
Anesthetic procedures have an effect on immune responses but the impact is only temporary.