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Related Experiment Videos

[The blood coagulating activity in burns]

V P Kotel'nikov, V N Morozov, V I Morozova

    Vestnik Khirurgii Imeni I. I. Grekova
    |January 1, 1996
    PubMed
    Summary

    Severe burns activate blood clotting and reduce clot breakdown in rats and patients. This study highlights significant hemostasis system imbalances following thermal trauma, impacting clotting factors and inhibitors.

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    Area of Science:

    • Biomedical Science
    • Hematology
    • Trauma Research

    Background:

    • Thermal trauma, such as burns, significantly impacts physiological systems.
    • Hemostasis, the process of stopping bleeding, involves complex interactions between procoagulant and anticoagulant factors.
    • Understanding hemostatic changes in burn patients is crucial for effective management.

    Purpose of the Study:

    • To investigate the alterations in the hemostasis system following thermal trauma.
    • To analyze the balance between procoagulant and anticoagulant pathways in burn patients and experimental models.
    • To identify specific changes in key hemostatic factors and inhibitors.

    Main Methods:

    • Experimental study involving 80 rats subjected to thermal trauma.
    • Clinical observations of 24 patients with II and IIIA degree burns.
    • Analysis of various hemostasis parameters, including clotting factors, anticoagulants, and fibrinolytic activity.

    Main Results:

    • Observed activation of the vasculo-thrombocytic and procoagulant hemostasis components.
    • Demonstrated depression of the anticoagulative blood system.
    • Noted a decrease in heparin, fibrinogen, antithrombin-III activity, fibrinolysis, and plasminogen activators.
    • Showed an increase in antiplasmins, specifically alpha 2-macroglobulin and alpha 1-antitrypsin.

    Conclusions:

    • Thermal trauma induces a significant shift in the hemostasis system towards a prothrombotic state.
    • The anticoagulative and fibrinolytic capacities of the blood are suppressed after burns.
    • These hemostatic changes are critical to consider in the clinical management of burn injuries.

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