Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perfluorocarbons: recent developments and implications for neurosurgery

D E Sakas1, K W Whittaker, R M Crowell

  • 1Neurosurgical Service, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Journal of Neurosurgery
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Giant lumbar meningocele in type-1 neurofibromatosis.

Hippokratia·2018
Same author

Training charter in spasticity neurosurgery added competence.

Acta neurochirurgica·2017
Same author

Intracranial hemorrhagic arachnoid cyst: the role of diffusion-weighted imaging.

The neuroradiology journal·2013
Same author

Training charter in epilepsy surgery added competence.

Acta neurochirurgica·2013
Same author

Transcranial alternating current stimulation reduces symptoms in intractable idiopathic cervical dystonia: a case study.

Neuroscience letters·2012
Same author

Twelve-year hospital outcomes in patients with idiopathic hydrocephalus.

Acta neurochirurgica. Supplement·2011
Same journal

A novel surgical T staging system for recurrent nasopharyngeal carcinoma: advancing prognostic accuracy and clinical applicability.

Journal of neurosurgery·2026
Same journal

De novo aneurysm formation and untreated aneurysm growth after microsurgical clipping: a 20-year prospective cohort study.

Journal of neurosurgery·2026
Same journal

Immune and clinicopathological features of molecularly defined prolactinoma subtypes.

Journal of neurosurgery·2026
Same journal

A nomogram predicting postoperative recurrence risk in SF1/TPIT nonfunctioning pituitary neuroendocrine tumors: integration of tumor heterogeneity quantification on T2-weighted imaging.

Journal of neurosurgery·2026
Same journal

Resection plus stereotactic radiosurgery versus stereotactic radiosurgery alone and control of brain metastasis-induced seizures.

Journal of neurosurgery·2026
Same journal

Predictors of ventricular shunt survival in neoplastic hydrocephalus: a retrospective cohort study of 239 patients.

Journal of neurosurgery·2026
See all related articles

Perfluorocarbons (PFCs) are advanced oxygen carriers with potential neurosurgical applications. Improved PFCs offer diagnostic and therapeutic benefits, including enhanced imaging and organ preservation.

Area of Science:

  • Biomedical Engineering
  • Neurosurgery
  • Medical Imaging

Background:

  • Perfluorocarbons (PFCs) have been studied for 30 years as oxygen carriers and potential blood substitutes.
  • Early PFCs faced limitations like instability, short half-life, and toxicity concerns, hindering clinical use.
  • Second-generation PFCs utilize improved emulsifiers, such as egg-yolk phospholipids, enhancing their tolerability and efficacy.

Purpose of the Study:

  • To review recent advancements in perfluorocarbon technology for oxygen delivery.
  • To explore the potential diagnostic and therapeutic applications of PFCs in neurosurgery.
  • To assess the role of PFCs in neuroimaging, cerebral protection, and organ transplantation.

Main Methods:

  • Review of recent developments in perfluorocarbon (PFC) technology and applications.

Related Experiment Videos

  • Analysis of diagnostic uses including assessment of cerebral blood flow, oxygen tension, and metabolism.
  • Evaluation of therapeutic applications such as cerebral protection, radiotherapy adjunct, and organ preservation.

    • Main Results:

    • Improved second-generation PFCs show promise due to better emulsifiers and reduced toxicity.
    • Diagnostic applications include enhanced imaging and staging of neurological diseases via CT, ultrasound, and MRI.
    • Therapeutic applications range from cerebral protection and radiotherapy support to organ preservation and ventilatory assistance.

    Conclusions:

    • Perfluorocarbons (PFCs) represent a promising area of development for advanced oxygen carriers.
    • PFCs have significant potential in neurosurgical practice for both diagnostic and therapeutic interventions.
    • Further research and clinical trials are warranted to fully realize the potential of PFCs in neurosurgery and related fields.