Related Experiment Videos
[Receptor mechanism of dynorphin A in rat secondary spinal cord injuries]
Objective:
To clarify the effects of dynorphin A on secondary spinal cord injuries.
Methods:
Spinal cord injured rat model made according to modified Allen's method was used by comparing the effect of intrathecal dynorphin A antiserum and that of its receptor antagonist nor-BNI.
Results:
The recovery of the muscle tension and motor function of the hindlimb in dynorphin antiserum group was markedly faster than that in both control and nor-BNI groups. Also, the recovery of motor function in the nor-BNI group was favorable at the early stage of injury, compared to the control group. Pathological observation showed that the residual area of the spinal cord in dynorphin A1-13 antiserum group was larger than that in both control and nor-BNI groups. The residual area of the spinal cord in the nor-BNI group was also larger than that in the control group.
Conclusion:
These observations support the hypothesis that dynorphin contributes to certain pathophysiological changes following traumatic SCI through both opiate-receptor mediated and nonopioid mechanisms.