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[Prevention and treatment effect of niacin on FES: experimental study]
Objective:
On the basis of fat embolism syndrome animal model injected with homologous dog bone marrow fat, we probed into the prevention and treatment effect of niacin on FES.
Methods:
Fourteen dogs were divided into experimental group and control group. In the experimental group, the dogs were injected with homologous dog bone marrow fat accompanied by niacin injection 4 mg/kg. 8 hr intravenously for 48 hours, while in the control group, only bone marrow fat was injected. PaO2, FFA, triglyceride, platelet counts, fat drops in the blood clots of vein were examined at different times. Finally, morphology and pathology of the lungs were observed.
Results:
There were a slower decrease in PaO2 and platelet counts and no obvious increase in triglycerides and FFA in the experimental group. The amount and diameter of fat drops in the blood clots of vein and in the lungs were less in the experimental group than in the control. Pathological examinations of the lungs demonstrated much less injuries in the experimental group.
Conclusion:
Good prevention and treatment effect of niacin on fat embolism syndrome is suggested.