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Brain-derived neurotrophic factor reversed experience-dependent synaptic modifications in kitten visual cortex

R A Galuske1, D S Kim, E Castren

  • 1Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany.

The European Journal of Neuroscience
|July 1, 1996
PubMed
Summary
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Brain-derived neurotrophic factor (BDNF) counteracts effects of monocular deprivation in the developing visual cortex. BDNF infusion shifted ocular dominance towards the deprived eye, impacting neuronal orientation selectivity.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Visual System Research

Background:

  • Experience-dependent plasticity shapes the visual cortex during development.
  • Monocular deprivation (MD) causes competitive repression of visual input.
  • Brain-derived neurotrophic factor (BDNF) synthesis is regulated by visual input, suggesting a role in MD effects.

Purpose of the Study:

  • To investigate the effects of intracortical BDNF and nerve growth factor (NGF) on MD-induced changes in the kitten visual cortex.
  • To determine if neurotrophic factors can modulate experience-dependent visual cortex development.

Main Methods:

  • Kittens underwent MD for one week during a critical developmental period.
  • Intracortical infusions of BDNF, NGF, or cytochrome C were administered.

Related Experiment Videos

  • Neuronal responses were monitored using optical and single-unit recording techniques.

    • Main Results:

    • NGF and cytochrome C had no significant effect on MD consequences.
    • BDNF infusion shifted ocular dominance towards the deprived eye near the infusion site.
    • High BDNF concentrations led to a loss of orientation selectivity and paradoxical afferent disconnection.

    Conclusions:

    • BDNF antagonizes the functional effects of monocular deprivation in the developing visual cortex.
    • BDNF plays a critical role in regulating visual input competition and cortical plasticity.