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Effects of dobutamine on left ventricular diastolic performance are attenuated in patients with systemic hypertension
M Iwakami1, Y Hashimoto, T Oniki
1Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
The American Journal of Cardiology
|August 1, 1996
Insights
Low-dose dobutamine improved heart relaxation in healthy individuals but not in those with untreated hypertension. This suggests impaired diastolic function in hypertension.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Hypertension is a common condition associated with cardiovascular complications.
- Diastolic dysfunction is an early indicator of cardiac impairment in hypertensive patients.
Purpose of the Study:
- To investigate the effect of low-dose dobutamine on left ventricular diastolic function in untreated hypertensive subjects.
- To compare the response to dobutamine in hypertensive individuals versus healthy controls.
Main Methods:
- Doppler echocardiography was used to measure diastolic parameters.
- Low-dose dobutamine was infused during the measurements.
- The study included 14 untreated hypertensive subjects and 14 normal controls.
Main Results:
- Low-dose dobutamine significantly accelerated left ventricular relaxation in normal controls.
- This acceleration of relaxation was not observed in the untreated hypertensive subjects.
- Doppler echocardiographic diastolic parameters showed a differential response between the groups.
Conclusions:
- Untreated hypertension may be associated with impaired left ventricular relaxation response to dobutamine.
- Low-dose dobutamine can unmask subtle diastolic dysfunction in hypertensive individuals.
- Further research is needed to understand the mechanisms behind this impaired response.
Abstract:
We measured Doppler echocardiographic diastolic parameter during infusion of low-dose dobutamine in 14 untreated hypertensive subjects and in 14 normal controls. Low-dose dobutamine accelerated left ventricular relaxation in normal controls but not in hypertensive subjects.