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Molecular mechanisms of drug inhibition of DNA gyrase
R J Lewis1, F T Tsai, D B Wigley
1Laboratory of Molecular Biophysics, University of Oxford, UK.
Abstract:
DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X-ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.