The R3 component of the blink reflex: normative data and application in spinal lesions

The clinical value of the R3 component (R3) of the blink reflex (BR) for differentiating between lesions at the medulla oblongata and cervical spinal cord level is still unclear. In 50 healthy volunteers (25 women, 25 men, aged 20-75 years) reproducible ipsi- and contralateral R3 responses could be evoked showing a mean onset latency of 84 ms, a duration of 32 ms and a side-to-side difference of almost 3 ms. The latency increased with age. Eleven patients with lesions of the cervical spinal cord (segments C1-C6) showed normal R3 latencies. In 4 patients with pathology of the brain-stem, however, R3 was abnormal, showing identical changes as observed with the R2 component. Our results suggest that the reflex arc of R3 does not descend to the cervical spinal cord but within the brain-stem possibly takes the same connections as the R2 component.