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Related Experiment Videos

[Corticoid resistance in asthma]

M Perrin-Fayolle1, F Gormand

  • 1Centre Hospitalier Lyon-Sud, Pierre-Bénite.

Revue De Pneumologie Clinique
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Corticosteroid resistance, a complex issue arising from improper treatment, affects inflammatory cells. Current alternative therapies show limited success, necessitating further research into underlying mechanisms.

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Area of Science:

  • Immunology
  • Pharmacology
  • Cell Biology

Context:

  • Corticosteroid therapy is a cornerstone in managing inflammatory conditions.
  • Incorrect application or treatment adaptation can lead to corticoresistance.
  • The phenomenon of corticoresistance presents varied clinical expressions affecting effector cells.

Purpose:

  • To explore the challenges and underlying mechanisms of corticoresistance.
  • To review the efficacy of alternative treatments for corticosteroid-resistant inflammation.

Summary:

  • Corticoresistance stems from improper corticosteroid use, impacting inflammatory cell responses.
  • Mechanisms involve acquired or genetic desensitization of receptor cells.
  • Alternative treatments like methotrexate, gold salts, and cyclosporin A have yielded limited positive outcomes.

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Impact:

  • Highlights the clinical challenge of corticoresistance in inflammatory diseases.
  • Underscores the need for better understanding of resistance mechanisms.
  • Suggests a gap in effective alternative therapies for corticosteroid-resistant conditions.