[Lens epithelial proliferation induced by macrophages after intraocular lens implantation in rabbits]

To approach the effect of intraocular lens implantation on the mechanism of posterior capsular opacification, the pathological changes of posterior lens capsule after intraocular lens implantation in rabbits were observed by transmission electron microscopy. The results were as follows: In the control group, 1 week after the operation and the injection of the medium of the macrophage suspension, the lens posterior capsule was covered by a layer of lens epithelium and until post-operative 6 months, the lens epithelium remained normal. In the experimental group, 1 week after the operation and the injection of the macrophage suspension into the anterior chamber, microfilaments appeared in the cytoplasm of lens epithelial cells, after 2 weeks, the lens epithelial cells produced collagen fibrils in the extracellular matrix and until postoperative 3 months, 2-3 layers of the lens epithelium proliferated in front of the posterior capsule and a large amount of collagenous fibers were formed around the cells. It is suggested that the macrophage promote the lens epithelial proliferation and the posterior capsular opacification.