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[Peripheral neuropathies caused by disulfiram]

P Dano¹, D Tammam, C Brosset

¹Service de Neurologie, Hôpital d'Instruction des Armées Laveran, Marseille.

Revue Neurologique

|April 1, 1996

Summary

Disulfiram, a medication for alcoholism, can rarely cause peripheral neuropathy. This nerve damage is dose-dependent, typically occurring at doses of 250 mg/day or higher.

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Area of Science:

Neurology
Toxicology
Pharmacology

Background:

Disulfiram is a widely used medication for managing chronic alcoholism.
Peripheral neuropathy is a potential, though uncommon, adverse effect associated with its use.

Observation:

A case study of a 42-year-old male patient experiencing peripheral neuropathy is presented.
Clinical features, electrophysiological findings, and pathology results were documented.

Findings:

Disulfiram-induced peripheral neuropathy is a dose-dependent condition.
Neuropathy typically manifests at daily doses of 250 mg or higher.

Implications:

Highlights the importance of monitoring for neurological side effects in patients taking disulfiram.
Suggests a need for further research into the underlying mechanisms of disulfiram neurotoxicity.

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