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Familial distal arthrogryposis type I
1Service de Génétique Médicale, Centre Hospitalo-Universitaire, Strasbourg, France.
Annales De Genetique
|January 1, 1996
Summary
Distal arthrogryposis type I causes joint contractures, primarily affecting hands and feet. This autosomal dominant condition exhibits significant variability in symptoms, even within families.
Area of Science:
- Medical Genetics
- Orthopedics
- Developmental Biology
Background:
- Distal arthrogryposis type I (DA1) is an autosomal dominant disorder characterized by congenital joint contractures.
- DA1 typically involves contractures of the hands and feet, with hand involvement being more frequent (98%) than foot involvement (88%).