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Invasive fungal sinusitis in immunosuppressed patients. Report of three cases
E Zapater1, M Armengot, A Campos
1Department of ENT, University General Hospital, Valencia, Spain.
Abstract:
Report of three cases. Newly appeared immunosuppression related conditions have led to an increase in morbidity of systemic opportunistic mycoses. Rhinosinusal infection has also increased in frequency. Three invasive nasosinusal mycoses are presented: two cases of mucormycosis and a simultaneous infection by mucormycosis and candida albicans. In all cases, and despite treatment, progression of the disease could not be stopped and the patients died. The main characteristics of invasive nasosinusal mycoses are reviewed, to obtain early diagnosis. Early therapy improves the prognosis, and thus clinical suspicion justifies treatment before establishing a microbiological diagnosis.
Insights
Newly emerged immunosuppression has increased opportunistic fungal infections, including invasive nasosinusal mycoses. Early diagnosis and treatment are crucial, as aggressive fungal infections like mucormycosis can be fatal despite intervention.
Area of Science:
- Mycology
- Infectious Diseases
- Otolaryngology
Background:
- Rising incidence of opportunistic mycoses linked to new immunosuppression-related conditions.
- Increased frequency of rhinosinusal infections observed in clinical settings.
Observation:
- Presentation of three cases of invasive nasosinusal mycoses.
- Two cases involved mucormycosis; one case showed a simultaneous infection of mucormycosis and Candida albicans.
Findings:
- Disease progression was relentless in all cases, leading to patient mortality despite treatment.
- Invasive nasosinusal mycoses, particularly mucormycosis, present a severe clinical challenge.
Implications:
- Early diagnosis of invasive nasosinusal mycoses is critical for improving patient prognosis.
- Clinical suspicion should guide prompt treatment initiation, even before definitive microbiological diagnosis.