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[Synthesis and properties of DNA duplexes with covalent bonds between cross-links]
S I Antsypovich1, T S Oretskaia, E A Romanova
1Genset Corporation, Paris, France.
Bioorganicheskaia Khimiia
|April 1, 1996
Abstract:
Synthesis of cross-linked modified DNA duplexes is described. The structure of the duplexes was confirmed by digestion with the AluI restriction endonuclease. Thermostability and resistance to enzymatic hydrolysis of the cross-linked duplexes were studied.