Impact of sar and agr on methicillin resistance in Staphylococcus aureus
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Updated: Oct 13, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
S Píriz Durán1, F H Kayser, B Berger-Bächi
1Department of Medicine and Animal Health, Faculty of Veterinary Medicine, University of Extremadura, Cáceres, Spain.
Abstract:
The global regulators agr and sar control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in the number of cells in the subpopulation expressing high methicillin resistance. The amount of low affinity penicillin-binding protein PBP2', the prerequisite for methicillin resistance, was apparently not affected, however, a reduction in PBP1 and PBP3 production was observed, suggesting that these resident PBPs of the cells might be involved somehow together with PBP2' in high level methicillin resistance.
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