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[Theophylline poisoning in children]

P E Jira1, B A Semmekrot, T B Vree

  • 1Afd. Kindergeneeskunde, Academisch Ziekenhuis, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|August 3, 1996
PubMed
Summary

Severe theophylline intoxication in infants can cause vomiting, agitation, and tachycardia. Prompt treatment, like peritoneal dialysis or haemoperfusion, is crucial for survival and recovery without lasting effects.

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Area of Science:

  • Pediatric Toxicology
  • Clinical Pharmacology

Background:

  • Theophylline is a medication used to treat respiratory diseases.
  • Severe intoxication can occur, particularly in infants, necessitating prompt medical intervention.

Observation:

  • Three infants (1, 3, and 9 months) presented with severe theophylline intoxication.
  • Serum theophylline concentrations ranged from 44 to 156 mg/l.
  • Clinical manifestations included vomiting, agitation, tachycardia, seizures, and cardiac arrhythmias.

Findings:

  • All three infants survived and recovered fully without sequelae.
  • Peritoneal dialysis was performed on one patient.
  • Haemoperfusion is identified as a definitive treatment for severe cases.

Implications:

  • Early recognition and management of theophylline toxicity are vital in pediatric patients.
  • Haemoperfusion should be considered for severe theophylline intoxication to ensure favorable outcomes.

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