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Proteasome: from structure to function
D Stock1, P M Nederlof, E Seemüller
1Abteilung Strukturforschung, Max-Planck-Institut für Biochemie, Martinsried, Germany. stock@biochem.mpg.de
Current Opinion in Biotechnology
|August 1, 1996
Abstract:
During the past two years, significant progress has been made in understanding the structure and function of the proteasome. Recent work has revealed the three-dimensional structure of the 700 kDa proteolytic complex at atomic resolution and elucidated its novel catalytic mechanism. Close relationships to a number of other amino-terminal hydrolases have emerged, making the proteasomal subunits the prototype of this newly discovered structural superfamily.