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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
10:53

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Published on: July 3, 2013

Circadian relationships between circulating atrial natriuretic peptides and serum calcium and phosphate in healthy

D L Vesely1, R B Sothern, L E Scheving

  • 1Department of Internal Medicine, University of South Florida Health Sciences Center, Tampa, USA.

Metabolism: Clinical and Experimental
|August 1, 1996
PubMed

Insights

Atrial natriuretic peptides (ANPs) like ANF, LANP, and VSDL show significant circadian rhythms in healthy humans. These rhythms are inversely related to serum calcium and phosphate levels, suggesting ANPs modulate these minerals.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Mineral Metabolism

Background:

  • Atrial natriuretic peptides (ANPs), including long-acting natriuretic peptide (LANP), vessel dilator (VSDL), and atrial natriuretic factor (ANF), are circulating human hormones.
  • ANF is known to decrease intracellular calcium concentrations.

Purpose of the Study:

  • To investigate the relationship between atrial natriuretic peptides and serum calcium and phosphate levels in healthy individuals.
  • To determine if ANPs influence the circadian rhythms of serum calcium and phosphate.

Main Methods:

  • Analysis of 21 24-hour profiles in 14 healthy humans.
  • Measurement of serum concentrations of VSDL, LANP, ANF, calcium, and phosphate.

Main Results:

  • VSDL, LANP, and ANF exhibited significant circadian rhythms (P < .001), peaking around 4:00 AM.
  • Serum calcium and phosphate also showed significant circadian rhythms (P < .001), with troughs opposing ANP peaks.
  • Circadian patterns of ANPs closely mirrored those of parathyroid hormone (PTH).

Conclusions:

  • Atrial natriuretic peptides may play a role in modulating the circadian rhythms of serum calcium and phosphate.
  • The similar circadian rhythms of ANPs and PTH suggest potential overlap in their physiological effects.
  • Some functions attributed to PTH might be mediated by atrial natriuretic peptides.

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