Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic rebound

P C Dau1

  • 1Department of Medicine, Evanston Hospital, IL 60201, USA.

Journal of Clinical Apheresis
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Therapeutic plasmapheresis (TP) may stimulate the immune system, potentially leading to antibody rebound. This immune stimulation might enhance the removal of autoreactive lymphocytes, benefiting autoimmune conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term effects of low-density lipoprotein apheresis using an automated dextran sulfate cellulose adsorption system. Liposorber Study Group.

The American journal of cardiology·1998
Same author

Intrafamily fragment analysis of the T cell receptor beta chain CDR3 region.

Journal of immunological methods·1995
Same author

Increased antibody production in peripheral blood mononuclear cells after plasma exchange therapy in multiple sclerosis.

Journal of neuroimmunology·1995
Same author

Atherosclerotic plaque evolution in the descending thoracic aorta in familial hypercholesterolemic patients. A transesophageal echo study.

Arteriosclerosis and thrombosis : a journal of vascular biology·1994
Same author

Immune modulation during treatment of systemic sclerosis with plasmapheresis and immunosuppressive drugs.

Clinical immunology and immunopathology·1994
Same author

Immunomodulation during treatment of polymyositis with plasmapheresis and immunosuppressive drugs.

Journal of clinical apheresis·1994

Area of Science:

  • Immunology
  • Autoimmunity
  • Therapeutic Apheresis

Background:

  • Fragmentary evidence suggests antibody (Ab) rebound or overshoot post-therapeutic plasmapheresis (TP).
  • In vitro studies indicate TP may cause immunostimulation via removal of regulatory molecules, increasing lymphocyte turnover and immunoglobulin production.
  • Immunoglobulin G (IgG) antibodies can downregulate B cells through antigen (Ag) and Fc receptor cross-linking.

Purpose of the Study:

  • To investigate the potential immunostimulatory effects of TP.
  • To explore the hypothesis that TP may selectively eliminate autoreactive lymphocytes.
  • To examine the impact of TP on autoantibody levels compared to total immunoglobulin.

Main Methods:

  • Review of existing clinical and experimental evidence on TP and immune responses.

Related Experiment Videos

  • In vitro studies on lymphocyte turnover and immunoglobulin production after TP.
  • Analysis of autoantibody and total immunoglobulin levels in patients treated with TP and cytotoxic immunosuppressives.

    • Main Results:

    • TP may lead to generalized immunostimulation by removing inhibitory regulatory molecules.
    • TP could preferentially delete proliferating lymphocytes, including those mediating autoimmunity.
    • TP combined with cytotoxic immunosuppressives showed a greater reduction in autoantibody levels than total immunoglobulin.

    Conclusions:

    • Therapeutic plasmapheresis might induce an immunostimulatory effect, potentially leading to antibody rebound.
    • TP may selectively target and reduce autoreactive lymphocytes, offering a therapeutic benefit in autoimmune diseases.
    • The observed reduction in autoantibodies suggests a specific depletion of pathogenic B cells or autoantibody-producing plasma cells.