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Blood acid-base changes during acute experimental inflammation in rats
V Alfaro1, J Ródenas, L Palaclos
1Department of Physiology, Faculty of Biology, University of Barcelona, Spain.
Canadian Journal of Physiology and Pharmacology
|March 1, 1996
Summary
Inflammation causes mixed acid-base disorders in rats, with metabolic acidosis and respiratory compensation. Despite these changes, blood pH homeostasis is maintained through complex ion and buffer shifts.
Area of Science:
- Physiology
- Biochemistry
- Pathology
Background:
- Inflammation is associated with acidosis in tissues.
- Changes in ion concentrations at the inflammation site can affect blood acid-base balance.
Purpose of the Study:
- To investigate blood acid-base variable changes during carrageenan-induced inflammation in rats.
- To understand the mechanisms maintaining hydrogen ion (H+) homeostasis during inflammation.
Main Methods:
- Induction of inflammation using carrageenan in rats.
- Measurement of blood acid-base variables at 12, 24, and 48 hours post-induction.
- Analysis of plasma strong ion difference ([SID]) and total weak acid concentration ([ATOT]) including inorganic phosphate ([ATOT]P(i)) and albumin ([ATOT]Alb).
Main Results:
- A mixed acid-base disorder was observed, characterized by metabolic acidosis (decreased [SID], increased [ATOT]P(i)) and respiratory compensation (hypocapnia).
- Changes in plasma [SID] and [ATOT]P(i) were linked to ion exchange with inflammatory exudate.
- Decreased plasma albumin ([ATOT]Alb) contributed to counteracting acidity.
Conclusions:
- Carrageenan-induced inflammation triggers metabolic acidosis and respiratory compensation in rats.
- Despite significant acid-base disturbances, hydrogen ion (H+) homeostasis is maintained, preserving blood pH.
- Ion shifts and buffer concentration changes play crucial roles in acid-base balance during inflammation.