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A porcine model of chronic peripheral arterial occlusion
1Department of Radiological Science, University of California, School of Medicine, Los Angeles 90024.
Purpose:
To create a simple and reproducible model of chromic thrombosis for the evaluation of thrombolytic agents and devices.
Materials And Methods:
A stenosis was created in the superficial femoral artery of domestic swine, and autologous blood clot was deposited above the stenosis. Follow-up last for up to 3 months. Degree of clot organization was determined at histologic examination. Two thrombolytic agents, urokinase and collagenase, were used to test this model.
Results:
There was a 27% delayed recanalization rate with this model. At histologic examination, early thrombus organization was seen at the vessel periphery after 10 days. One-month-old thrombus was substantial but variable in amount. Three-month-old thrombus was completely organized. Neither urokinase nor collagenase proved effective against chronic clot in the doses and time course of this study.
Conclusion:
This simple method yields a chronic porcine clot in a reliable number of domestic swine in 1 month.