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Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a
J S Krasnow1, S L Berga, D S Guzick
1Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
Objective:
To determine whether serum levels of vascular permeability factor (VPF) are elevated in patients with ovarian hyperstimulation syndrome (OHSS) and to determine if luteinizing granulosa cells may be a source of VPF.
Design:
Prospective observational study.
Setting:
University IVF and GIFT program.
Patients:
Eight consecutive IVF and GIFT patients at high risk for OHSS.
Main Outcome Measures:
Vascular permeability factor concentration in serum and follicular fluid.
Results:
Serum VPF was significantly higher (15.2 +/- 4.0 pM; mean +/- SEM) on day +14 in the group who developed severe OHSS compared with those who did not. Follicular fluid VPF (171.5 +/- 18.5 pM) was approximately 100-fold greater than serum (1.7 +/- 1.3 pM) or peritoneal fluid (2.5 +/- 1.3 pM) 36 hours after hCG administration.
Conclusion:
Vascular permeability factor is elevated in patients with severe OHSS and the ovary may be a source of VPF secretion.