Evolving therapies for peptic ulcer disease: Helicobacter pylori treatment

In the era of Helicobacter pylori, our concepts about peptic ulcer disease have undergone a major paradigm shift. New ways of thinking about the etiology of ulcers are leading to new treatment modalities. Treating peptic ulcers with antibiotics is an idea that would have been laughed at a mere decade ago, yet it has become the standard of care for H. pylori-associated disease. Our current state of knowledge, and where we seem to be heading, is the subject of this review.