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Clinical trials of Astemizol in children with cow's milk hypersensitivity
B Cudowska1, D Korol, M Kaczmarski
1Third Department of Pediatrics, Medical Academy of Białystok.
Insights
Food hypersensitivity to cow's milk is linked to various symptoms in children. Astemizol treatment showed good therapeutic effects with minor side effects, proving useful for managing milk hypersensitivity.
Area of Science:
- Pediatrics
- Allergology
- Clinical Immunology
Background:
- Cow's milk hypersensitivity is a common concern in pediatric populations.
- Symptoms associated with milk hypersensitivity can affect multiple organ systems.
- Understanding the clinical manifestations and treatment efficacy is crucial for pediatric care.
Purpose of the Study:
- To investigate the relationship between food hypersensitivity to milk and various clinical symptoms in children.
- To evaluate the efficacy and safety of an elimination diet combined with Astemizol treatment in children with milk hypersensitivity.
Main Methods:
- Clinical and laboratory examinations were performed on 36 children aged 1 year 10 months to 11 years.
- An elimination diet and pharmacological treatment with Astemizol were administered to all participants.
- Symptom relief and adverse effects were systematically recorded.
Main Results:
- A strong correlation was observed between milk hypersensitivity and symptoms affecting the skin (81%), respiratory tract (61% upper, 55% lower), digestive tract (47%), and central nervous system (14%).
- Complete symptom relief was achieved in 39% of children, with 44% experiencing improvement in one or two organ systems.
- Reported side effects of Astemizol included increased appetite (22%), weight gain (3%), vomiting (3%), diarrhea (3%), epistaxis (3%), and somnolence (5%).
Conclusions:
- A close relationship exists between cow's milk hypersensitivity and a range of symptoms in children.
- Combined elimination diet and Astemizol treatment demonstrated significant therapeutic benefits for milk hypersensitivity.
- Astemizol is considered a useful adjunctive treatment due to its good efficacy and tolerable side effect profile in pediatric patients.
Abstract:
A group of 36 children aged from 1 10/12 to 11 years was the subject of clinical and laboratory examinations. It was found that there is a close relationship between food hypersensitivity to milk and symptoms of the skin (81%), upper (61%) and lower (55%) respiratory tract, digestive tract (47%) and central nervous system (14%). These symptoms occured in isolated or associated forms on the different organs or systems. An elimination diet and pharmacological treatment with Astemizol were used in all children from the investigated group. Complete relief of symptoms was observed in 39% of children; 44% of examined patients had a regression of symptoms of 1 and/or 2 organs. Side effects of treatment with Astemizol were observed in the form of excessive appetite (22%), body weight gain (3%), vomiting (3%), diarrhoea (3%), bleeding from the nose (3%), sleepiness (5%). Due to the good therapeutic effect and insignificant side effects, the supporting pharmacological treatment with Astemizol was found useful in children with hypersensitivity to cow's milk.