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Experimentally contaminated reabsorbable meshes: their evolution in abdominal wall defects
G C López Villalta1, V Furió-Bacete, E Ortiz Oshiro
1Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain.
International Surgery
|July 1, 1995
Summary
Polyglycolic acid reabsorbable meshes show good tolerance even when contaminated with septic materials during abdominal wall defect repair. This study found no increased infection incidence, suggesting their safe use in contaminated environments.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Wound Healing
Background:
- Septic contamination poses challenges for evaluating reabsorbable prostheses, potentially leading to abdominal fistulae.
- Reabsorbable meshes are crucial for abdominal wall defect repair, but their use in infected environments requires careful consideration.
Purpose of the Study:
- To evaluate the behavior and evolution of polyglycolic acid (PGA) reabsorbable meshes contaminated with septic materials.
- To assess the safety and efficacy of PGA meshes in treating abdominal wall defects under septic conditions.
Main Methods:
- An experimental study involving 40 Wistar rats with abdominal wall defects.
- Massive contamination of PGA meshes with fecaloid material in experimental animals.
Main Results:
- Polyglycolic acid reabsorbable meshes were well-tolerated despite massive septic contamination.
- No increased incidence of infection was observed throughout the mesh reabsorption process.
Conclusions:
- Reabsorbable PGA meshes can be safely used in contaminated settings for abdominal wall defect repair.
- Septic contamination did not compromise the tolerance or integration of PGA meshes in this experimental model.