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The inositol triphosphate receptor family
1Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA. josephs@jeflin.tju.edu
Cellular Signalling
|January 1, 1996
Abstract:
Specific receptors on intracellular membranes mediate the Ca2+ mobilization induced by the second messenger molecule D-myo-inositol 1,4,5-triphosphate (IP3). Most cell types appear to contain multiple receptor isoforms. The review summarizes recent progress on IP3 receptor biology with a particular emphasis on distinctive structural and regulatory features of the individual isoforms.