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[Etiologic factors of urinary lithiasis in Tunisian children]
Insights
Urinary stones in Tunisian children are often linked to phosphorus deficiency or urinary tract infections. Hereditary metabolic diseases also contribute to stone formation in pediatric cases.
Area of Science:
- Pediatric Nephrology
- Urology
- Biochemistry
Abstract:
Fifty-five Tunisian children with urinary stones, between the ages of 8 months and 15 years, underwent morphological and infrared spectrophotometric analysis of their stones. This study provides an approach to the aetiological profile of urinary stones in Tunisian children. The nucleus of the stones was composed of acidic ammonium urate in 48% of cases with a morphology suggestive of phosphorus deficiency associated with a history of diarrhoea. In 24% of cases, the nucleus contained struvite indicating the presence of urinary tract infection by urease-positive bacteria. The main growth factors of urinary stones were hyperoxaluria and urinary tract infection. In 5 cases, the stones were due to a hereditary lithogenic metabolic disease : cystinuria in 1 case and primary hyperoxaluria in 4 cases.