Related Experiment Videos
[Effect of imipramine hydrochloride on urinary function and serum parameters in enuretic children: preliminary study]
S Siracusano1, P A Tomasi, R Mandras
1Département de l'Université d'Urologie de Trieste, Italie.
Insights
Imipramine hydrochloride (HCL) therapy reduces nighttime urine volume in children with primary nocturnal enuresis. This antidiuretic effect appears to stem from increased renal water resorption, not aldosterone involvement.
Area of Science:
- Pediatric Nephrology
- Clinical Pharmacology
Background:
- Primary nocturnal enuresis is common in children, with its exact antidiuretic mechanisms remaining unclear.
- Understanding the role of urinary and serum factors in enuresis is crucial for effective treatment.
Purpose of the Study:
- To compare urinary and serum factors between children with primary nocturnal enuresis and healthy controls.
- To investigate the effects of Imipramine hydrochloride (HCL) therapy on these parameters in enuretic children.
Main Methods:
- Evaluated daily/nightly urinary volume, fluid intake, plasma/urine osmolality, aldosterone, electrolytes, blood urea nitrogen, and glucose.
- Compared data between 9 enuretic children and 6 age/sex-matched controls using one-way ANOVA.
- Assessed changes following Imipramine HCL therapy.
Main Results:
- Enuretic children exhibited higher 24-hour urinary volume and lower urine osmolality than controls.
- Aldosterone levels did not appear to be a significant factor in enuresis pathogenesis.
- Imipramine HCL therapy objectively reduced urine volume in enuretic children.
Conclusions:
- Imipramine HCL is an effective treatment for primary nocturnal enuresis, reducing urine volume.
- The therapeutic mechanism of Imipramine HCL likely involves enhanced renal water reabsorption.
- Further research into Imipramine's antidiuretic properties in pediatric enuresis is warranted.
Abstract:
We still do not know whether Imipramine works exactly as an antidiuretic. The aim of this study was to investigate any existing urinary or serum factor differences between 9 children with primary nocturnal enuresis and six age and sex matched controls and to see if therapy with Imipramine could modify these parameters. All subjects underwent an evaluation of daily and nightly urinary volume, daily fluid intake, morning plasma and urine osmolality, plasma aldosterone, electrolytes, blood urea nitrogen and plasma glucose. The results, using a one-way ANOVA, would suggest the following: 1) enuretic children have a higher 24 urinary volume with a reduced osmolality compared to controls; 2) Aldosterone does not seem to be involved in the pathogenesis of enuresis; 3) Imipramine HCL therapy does reduce the volume of urine lost in diapers, and its efficiency can be documented objectively; 4) Imipramine HCL's mechanism appears to be related to an increased renal water resorption.