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Updated: Aug 9, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
[Do neonates and small infants feel pain?]
1Børneafdelingen, Hillerød Sygehus, Hillerød.
Insights
Infants and neonates perceive pain, but cannot communicate it. Accurate pain assessment in young children requires observer ratings and physiological measures to guide effective interventions.
Area of Science:
- Neonatal pain perception
- Neuroscience of pain in infants
- Pediatric pain pathways
Context:
- Infants and neonates possess pain pathways despite immaturity.
- Pain responses in infants involve complex central modulating mechanisms.
- Pain is subjective, posing challenges for non-verbal children.
Purpose:
- To highlight the complexities of pain assessment in infants and neonates.
- To emphasize the need for observer rating systems and physiological variables.
- To underscore the importance of thorough pain assessment for effective intervention.
Summary:
- Infants and neonates have the capacity for pain perception.
- Pain assessment in children under three relies on observer ratings and physiological data.
- Effective pain management requires accurate assessment, potentially through specialized pain services.
Impact:
- Improved pain management strategies for infants and neonates.
- Potential reduction of long-term negative effects of pain in early childhood.
- Enhanced understanding of pain processing in immature nervous systems.
Abstract:
Infants and even premature neonates, although immature, possess the basic pathways and nociceptors necessary for pain perception. Their responses to painful stimuli are complex, and indicate the presence of central modulating mechanisms. By definition, pain is a subjective experience, but children under the age of three years are unable to communicate their experience. Observer rating systems for pain assessment must take into account the variation in pain expression among infants. In many settings, measurement of different physiological variables are used as indices of pain experience and the effect of intervention. Although the beneficial effect of intervention is well established, it may also have an impact on the possible long-term effects in early childhood. Thorough pain assessment is a prerequisite for successful intervention, and may be improved by introduction of "pain services".
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