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Updated: Aug 18, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
[The characteristics of T-lymphocyte differentiation in type-1 diabetes mellitus]
Abstract:
Postthymic T-precursors were quantified in patients with diabetes mellitus (DM) varying in forms. The number of pre-T-lymphocytes and auto-rosette-forming cells was found to differ significantly in DM type I patients from that of healthy donors. The count of T-precursors was analyzed with regard of DM duration, pattern, ketoacidosis, diabetic microangiopathy, insulin dose, associated diseases. The findings justify introduction of immunomodulating therapy of DM type I patients with thymic drugs and thymomimetics.
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