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Related Experiment Videos

Sonic spray mass spectrometry

A Hirabayashi1, M Sakairi, H Koizumi

  • 1Central Research Laboratory, Hitachi, Ltd., Tokyo, Japan.

Analytical Chemistry
|September 1, 1995
PubMed
Summary

A new sonic spray ionization method efficiently produces ions from dilute solutions for mass spectrometry. This technique, utilizing a methanol-water spray, detects neurotransmitters like dopamine at low concentrations.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Chemical Physics

Background:

  • Traditional ionization methods face challenges with dilute solutions.
  • Understanding ion formation mechanisms is crucial for sensitive analysis.

Purpose of the Study:

  • To develop and characterize a novel sonic spray ionization (SSI) method.
  • To investigate ion and charged droplet formation in SSI.
  • To analyze dilute neurotransmitter solutions using SSI-MS.

Main Methods:

  • Developed a sonic spray ionization system using a fused-silica capillary with coaxial gas flow.
  • Analyzed positive ions from dilute catecholamine solutions (e.g., dopamine) using a quadrupole mass spectrometer.
  • Compared SSI with ion spray ionization (ISI) for dilute solution analysis.

Main Results:

  • Protonated dopamine molecules detected from a 10 nM solution.
  • Ion intensities correlate with gas flow rate.
  • Most ions originate from charged droplets, challenging traditional charging models.
  • Proposed a new model for charged droplet formation based on ion concentration distribution.

Conclusions:

  • Sonic spray ionization is effective for analyzing dilute solutions, including neurotransmitters.
  • The study provides insights into the fundamental mechanisms of ion and charged droplet formation in SSI.
  • The proposed charging model offers a new perspective on electrospray ionization processes.

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