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Commercially available antibodies to human interleukin-1 do not crossreact with porcine interleukin-1
1Department of Clinical Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Abstract:
Interleukin-1 (IL-1) is a key mediator in inflammatory processes. There are several immunoassays for human, but not porcine, IL-1 commercially available. Four of these were tested on porcine specimens. IL-1 was not detected, by any of the immunoassays, in cell culture supernatants with confirmed IL-1 activity in a bioassay. The results indicate that the tested antibodies to human IL-1 do not crossreact with porcine IL-1.