Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Muscle chemoreflex causes renal vascular constriction

S W Mittelstadt1, L B Bell, K P O'Hagan

  • 1Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, USA.

The American Journal of Physiology
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasmid CDS5 influences infectivity and virulence in a mouse model of Chlamydia trachomatis urogenital infection.

Infection and immunity·2014
Same author

The effect of aging on adrenergic and nonadrenergic receptor expression and responsiveness in canine skeletal muscle.

Journal of applied physiology (Bethesda, Md. : 1985)·2011
Same author

Is tonic sympathetic vasoconstriction increased in the skeletal muscle vasculature of aged canines?

American journal of physiology. Regulatory, integrative and comparative physiology·2010
Same author

Absence of flow-mediated vasodilation in the rabbit femoral artery.

Physiological research·2009
Same author

Dose-response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys.

British journal of pharmacology·2008
Same author

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG.

Journal of pharmacological and toxicological methods·2008
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

The muscle chemoreflex impacts renal vascular conductance, decreasing it when hindlimb blood flow is significantly reduced. This effect is independent of renal sympathetic nerve activity.

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Renal Physiology

Background:

  • The muscle chemoreflex is a critical cardiovascular reflex.
  • Its influence on renal vascular conductance, particularly in innervated versus denervated kidneys, requires further elucidation.

Purpose of the Study:

  • To investigate the role of the muscle chemoreflex in modulating renal vascular conductance.
  • To determine if renal sympathetic nerve activity mediates these effects.

Main Methods:

  • Experiments were conducted on six dogs subjected to treadmill exercise.
  • Muscle chemoreflex was stimulated by progressively reducing hindlimb blood flow (HLBF).
  • Arterial blood pressure and renal vascular conductance were monitored.

Related Experiment Videos

Main Results:

  • Significant reductions in HLBF led to increased arterial blood pressure and decreased renal vascular conductance.
  • Decreased renal vascular conductance occurred at similar HLBF thresholds in both denervated and innervated kidneys.
  • The observed changes were not significantly different between innervated and denervated kidneys.

Conclusions:

  • Reductions in hindlimb blood flow trigger a decrease in renal vascular conductance.
  • This response is independent of renal sympathetic nerve activity, suggesting non-neuronal mechanisms are involved.