Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An angiomyoma with t(X;10)(q22;q23.2)

H Sonobe1, Y Ohtsuki, H Mizobuchi

  • 1Department of Pathology, Kochi Medical School, Japan.

Cancer Genetics and Cytogenetics
|August 1, 1996
PubMed
Summary

A rare chromosomal translocation, t(X;10)(q22;q23.2), was identified in a patient's angiomyoma. This finding represents a unique case among benign tumors, contributing to the understanding of angiomyoma karyotypic abnormalities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bullous pemphigoid suggestive of complement-independent blister formation with anti-BP180 IgG4 autoantibodies.

The British journal of dermatology·2016
Same author

SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.

Oncogene·2013
Same author

S-100 protein-positive dendritic cells detected in hepatocellular-carcinoma in relation to tumor progression and prognosis.

International journal of oncology·2011
Same author

The aberrant p53 protein (review).

International journal of oncology·2011
Same author

Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2011
Same author

Secondary-phase-modulation method for open-loop fiber-optic gyroscopes.

Applied optics·2010

Area of Science:

  • Cytogenetics
  • Oncology
  • Pathology

Background:

  • Angiomyomas are benign tumors with limited known genetic alterations.
  • Previous studies have reported chromosomal rearrangements in some angiomyoma cases, such as 6p, 13q, and 21q abnormalities.

Observation:

  • A specific chromosomal translocation, t(X;10)(q22;q23.2), was identified as the sole aberration in primary cells of an angiomyoma from a 58-year-old woman.

Findings:

  • This t(X;10)(q22;q23.2) translocation has not been previously reported in other benign tumors, including leiomyomas and angiomyomas.
  • The identified translocation has been observed in an ependymoma, suggesting potential shared or convergent genetic mechanisms in different tumor types.
  • This case is considered the third reported instance of an angiomyoma exhibiting distinct karyotypic abnormalities.

Related Experiment Videos

Implications:

  • The identification of this novel translocation expands the known spectrum of genetic aberrations in angiomyomas.
  • Further research into this translocation may elucidate its role in the pathogenesis of angiomyomas and potentially other tumor types.
  • This finding contributes to the differential diagnosis and understanding of rare chromosomal abnormalities in benign neoplasms.