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Cardiac mitochondrial dysfunction in Leigh syndrome
J Marin-Garcia1, R Ananthakrishnan, M Korson
1Molecular Cardiology Institute, 75 Raritan Avenue, Highland Park, NJ 08904, U.S.A.
Pediatric Cardiology
|November 1, 1996
Abstract:
An infant with Leigh syndrome and associated cardiomyopathy is described. Abnormal activities of mitochondrial respiratory complexes III and V and a change in mtDNA at nt 8993 were detected in heart and skeletal muscle but not in liver.