Determination of saturation transfer parameters of human tissues in vivo

In order to study the applicability of magnetization transfer contrast (MTC) to tissue differentiation, the determination of the magnetization transfer (MT) parameters of normal tissues is necessary for the evaluation of pathological conditions. The time-dependent saturation transfer technique was used to investigate the observed magnetization transfer parameters in several human tissues in vivo at 0.1 T. The length of the off-resonance saturation pulse varied from 0 to 750 ms. The magnetization transfer contrast (MTC) was 0.71 in striated muscle, 0.49 in liver, 0.49 in renal cortex, and 0.50 in spleen. The observed magnetization transfer rates (Rwm) were 5.5 s-1 for muscle, 3.1 s-1 for liver, and 1.5 s-1 for both renal cortex and spleen. Our results indicate that measuring Rwm and possibly other relaxation parameters could be useful in tissue differentiation.