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On T cell memory: arguments for antigen dependence

T M Kündig1, M F Bachmann, P S Ohashi

  • 1Institute for Experimental Immunology, Zürich.

Immunological Reviews
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

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CD8+ T cell memory persists long-term after antigen exposure, detectable as elevated cytotoxic T cell precursor frequency (CTLp). However, effective immunity requires antigen-dependent activation for extravasation and effector function in nonlymphoid tissues.

Area of Science:

  • Immunology
  • Cellular immunology
  • T cell biology

Background:

  • T cell memory is crucial for adaptive immunity but its nature and antigen dependence remain debated.
  • While B cell memory is well-understood, CD8+ T cell memory is less characterized.
  • Investigating the persistence and functional requirements of CD8+ T cell memory is essential for understanding adaptive immunity.

Purpose of the Study:

  • To investigate the nature, duration, and antigen dependence of CD8+ T cell memory.
  • To clarify discrepancies in findings regarding T cell memory.
  • To elucidate the mechanisms underlying effective immunity against reinfection.

Main Methods:

  • Analysis of CD8+ T cell memory aspects.
  • Evaluation of cytotoxic T cell precursor frequency (CTLp) in lymphoid organs.

Related Experiment Videos

  • Assessment of T cell extravasation and effector function in peripheral tissues.

    • Main Results:

    • Antigen exposure induces a lasting shift in the T cell repertoire, marked by elevated CTLp in lymphoid organs.
    • In vitro memory assays remain positive even without antigen, due to T cells isolated from lymphoid organs.
    • Effective immunity against reinfection necessitates antigen-dependent activation for CTLp extravasation and function in nonlymphoid tissues.

    Conclusions:

    • CD8+ T cell memory is characterized by a persistent increase in CTLp in lymphoid organs, irrespective of ongoing antigen presence.
    • Elevated CTLp alone are insufficient for protective immunity.
    • Persistent antigen stimulation is critical for maintaining the functional readiness of memory CD8+ T cells in peripheral tissues for effective pathogen clearance.